E mail kirankalia_in@yahoo.com
Tel :+ 91 2692 234402 (O) + 91 2692 325051 (R)
9824335881 (cell )
Fax : +91 2692 231042
Address : School of Biosciences,
Post Box No. 39
Vallabh Vidyanagar – 388 120
Anand , Gujarat ,India
School of Biosciences, Sardar Patel University
Academic Qualification : M. Sc (Biochemistry) 1979
Ph.D. (Biochemistry) 1984
Research Interests:
Metal Toxicology , Protein Biochemistry , Immunology &
Environmental Biotechnology.
Research Experience: 22years
Ø Homogeneous manganese binding 63 KD glycoprotein without –SH groups was purified from brain, liver and serum tissue. The presence of manganese was found to increase the lead binding to its respective protein of 20 KD in brain, which may be a possible mechanism of enhanced neurotoxic effect due to co-exposure to the two metals.
Ø The metal (Mn, Pb, Ni, Cd, As, Zn) resistant bacterial cells isolated from industrial effluent showed accumulation of various metals were identified. Transmission electron microscopic and energy dispersive X-ray analysis (EDAX) data showed preferential accumulation of manganese by Pseudomonas aeruginosa in the cell wall with some invaginations followed by cytoplasm in the concentration dependent manner. Bacillus coagulans was found to bind with both lead (2 mM) and cadmium (0.6mM) with induction of 25 and 30 KD proteins by cadmium and only 25 KD membrane protein by lead, indicating their role in transport/accumulation of the metal.
Ø Arsenic accumulation and reduction in Pseudomonas Sp. was studied and metal coordination using XANES and EXAFS inside the cells suggesting the reduction of arsenate to arsenite. The metal resistant operon for arsenic named ars operon was characterized and sequenced which is encoded by three open reading frame transcribing in a same direction for the proteins ars R, ars B and ars C. (Gene bank accession No. AY702476) Studies on proteomic approach to characterize the arsenic induced and arsenic binding proteins in. using ion exchange, size exclusion chromatography and MALDI –TOF analysis are in progress
Ø Diabetes is not a single disease but a group of disorders having in common hyperglycemia. Occurrence of lipid peroxidation diabetic patients may be a result of decreased G6PDH, which along with glutathione peroxidase were reported for detoxification of oxygen radicals generated by the hemoglobin.
Ø Advanced glycosylation of protein, the toxic mediator of secondary complications and infections in diabetes mellitus resulted in decreased compliment binding efficiency.. Increased Glycosylation of IgG, IgA in type 1 and type 2 DM patients with nephropathy and a positive correlation suggesting the glycosylation of IgG as an equivalent marker for advanced glycosylation as GHb and may have some role to play in the on onset of diabetic nephropathy by altering their immuno reactivity leading to micro-vascular complications. Uninary excretion of IgG in diabetic individuals could be useful in early detection of diabetic nephropathy.
No. of Ph. D. students guided:
Completed - Thirteen
Working presently – Five
Research Projects Completed: Ten
Ongoing Research Projects : Three
- Biochemical and molecular characterization of arsenic accumulation by P. stutzeri DSM 5190 including the role of some thiol chelators for detoxification .
- Interaction of some micronutrients like fluoride, zinc and selenium with arsenic on the toxicity and its treatment
- Functional abnormality of glycosylated IgG in diabetes mellitus and their role in progression of secondary complication such as diabetic nephropathy
Memberships of Academic and Professional Bodies:
Indian Science
Society of Biological Chemists,
Society of
Indian Association of Micronutrients,
Previous Positions :
Sardar Patel University
Oct.1987 to Sept.98 Reader Teaching & Research Mar.1986 to Oct.87 Lecturer Teaching & Research
Nov.1985 to Feb.86 Research Associate Research
Industrial Toxicology Research Centre, Lucknow
April 1984 to Oct. 85 Research Associate Research
Jan. 1980 April 84 Research Fellow* Research
· Awarded JRF, SRF and Research Associate ship as a direct fellow of Council of Scientific and Industrial Research, New Delhi , India
Awards / Honors Received
Ø Awardees of Government of India National Award of Bharat Scout and Guide 1974 by His Excellence President of India Shri V.V. GIRI recognizing as PRESIDENT GUIDE of India
Ø Awarded Overseas research associate ship of Department of Biotechnology, New Delhi, 2006-7 to work at
Ø Awarded visiting Fellowship of Indian National Science Academy, New Delhi, 1991-92 to work at National Institute of Immunology,
Ø Awarded Council of Scientific and Industrial Research Fellowships JRF, SRF, PDF and Research Associate ship during pre and post Ph.D. research
Ø Associate fellow of
Ø Member of Editorial Board of Journal of cell and Tissue Research.
Ø Member of Editorial Board of Journal of Environmental Biology.
Research Publications:
i. Research Papers -43
ii. Paper Presentation -40
Recent Publications-
Kiran Kalia, Wendy Jiang, and Wei Zheng 2008 Manganese primarily accumulates in nucleus of cultured brain cells Neurotoxicology -
Kiran Kalia , Gagan Deep Narula, G.M.Kannan and S.J.Flora. 2007. Effects of combined administration of captopril and DMSA on arsenite induced oxidative stress and blood and tissue arsenic concentration in rats. Comparitive Biochemistry and Physiology , Part C 144, 372-379
Prerna patel, Florence Goulhen, Chistopher Boothman, Andrew G. Gault, John M. Charnock, Kiran Kalia, Jonathan R. Lloyd 2007. Arsenate detoxification in a Pseudomonad hypertolerant to arsenic. Arch. Microbiology-187(3) 171-183
Gaurav S. Dave and Kiran Kalia 2007 Hyperglycemia induced oxidative stress in type-1 and type-2 diabetic patients with and without nephropathy.
Cellular and Molecular Biology 53,68-78
KiranKalia, Jagdish S.Patel and Prerna Patel2005. Isolation and characterization of nickel uptake by nickel resistant bacterial isolate (NiRBI).
Biomed. Environ. Sci. 19,110-117
Kalia K., Patel J.S., Joshi D.N.and Srivastave D 2006. Isolation of zinc resistant bacterial isolates, its accumulation and interaction with cellular proteins.J. of Cell and Tissue Research 6,651-656
Kiran Kalia and Swaran J.S.Flora. 2005. Strategies for safe and effective therapeutic measures for chronic arsenic and lead poisoning- A Review.Journal of occupational health : 47:205 (1): 1-25.
Jignesh H. Trivedi, Kiran Kalia, Natu K. Patel, and H. C. Trivedi 2005. Modification of sodium salt of partially carboxymethylated Guar Gum by Graft copolymerization with Methyl Acrylate.
Polymers & Polymer Composites 13,01-09
Jignesh H. Trivedi, Kiran Kalia, Natu K. Patel and H. C. Trivedi 2005. Ceric-induced grafting of vinyl monomers onto sodium salt of partially carboxy methylated Guar Gum: Effect of substrate structure and liquor ratio. J. Pure & Applied.Science. 13, 44-56
Jignesh H. Trivedi, Kiran Kalia, Natu K. Patel and H. C. Trivedi 2005. Grafting of vinyl monomers onto sodium salt of partially carboxymethylated Guar Gum: Comparison of their reactivity.
Polymer-Plastics Technology. & Engineering- 44,01-11
Jignesh H. Trivedi,Kiran Kalia, Natu K. Patel and H. C. Trivedi. 2005. Graft copolymerization of sodium salt of partially Carboxymethylated Guar Gum with Methyl Methacrylate: an Examination of reaction Variables. J. of Polymer Science 96,1855-
Jignesh H. Trivedi, Kiran Kalia, Natu K. Patel and H. C. Trivedi. 2005. Ceric-Induced Grafting of Acrylonitrile onto Sodium salt of partially Carboxy methylated Guar Gum. Carbohydrate Polymers 60,117-
Kiran Kalia, Seema Sharma and Kinnari Mistry.2004. Non enzymatic glycosylation of immunoglobulins in Diabetic nephropathy.
Clin. Chem. Acta.347 ,169-176
Manoj modi, Uma Pathak, Kiran Kalia and S. J. S. Flora. 2004
co-administration of Zinc during chelation of arsenic with monoisoamyl
DMSA in Male Mice.
Environ. Toxico &Appl. Pharma.19, 131-138.
Kiran Kalia and Prerna C Patel. 2004. Mechanism of arsenic resistance in microorganisms- A Review. Journal of Tissue research: 5(1):369-380
KiranKalia, K.V.Pavani, Jagdish S. Patel and Prerna Patel.2003. Cell envelope protein induction in Bacillus Coagulans by accumulation of lead and cadmium.
Asian J. Microbiol. Biotech. & Environ. Sci. 5 (4), 533-536
Invited Lectures/Presentations (2002-2007):
Ø Delivered guest lectures at, University Putra
Ø
Ø National
Ø Series of lectures were delivered at Department of Biochemistry,
Ø Resource person and delivered two lecture at “Biotechnology and Bioprocess Engineering programme under ISTE at DDIT, Nadiad, Dec. 2003
Ø Series of lectures to faculty members of Dept. of Biological Sciences (Botany, Zoology, Biotechnology and Microbiology) at
Ø “NIDDM and oral anti diabetic” Invited lecture at workshop on “Introduction to drug discovery” at PERD Centre , Ahmedabad 2004
Ø Resource person in UGC sponsored refresher course at Dept. of microbiology,
Ø Resource person in UGC sponsored refresher course at Dept. of Botany,
Ø Resource person in one month winter school at department of Biosciences,
Ø Invited lecture entitled “Arsenic resistance in Microbial cells” at Defense Research and Development Establishment (DRDE), Gwalior 2004.
Ø Invited lecture entitled “Arsenic detoxification in microbial cells” at Defense Reseach Laboratory, Tejpur (
Ø Invited Talk “ Beneficial effects of Zincsupplementation during chelation of arsenic with monoisoamyl DMSA in male mice “ -7th International Symposium on chelating agents in Biomedicine, Toxicology and Therapeutics (2004) at
Ø Invited Talk” Role of reactive oxygen species( Oxidative Stress) in the etiology of Diabetic Complications” 4th World congress on Cellular and Molecular Biology (2005) at